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Image Search Results
Journal: eLife
Article Title: A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal
doi: 10.7554/eLife.05105
Figure Lengend Snippet: ( A and B ) Ambulatory activity recorded by telemetry implants across multiple days (left) and averaged over 24 hr (right). Traces represent 2-hr recursive smoothing (black) of the underlying raw DATa (dark grey; SEM envelope, light grey). Areas in yellow indicate lights on. ( C ) Amplitude spectral density in the ultradian range (2–8 hr) is significantly different between Slc6a3 −/− mice and their wildtype littermates revealing a loss of the ultradian component (mean ± SEM; N = 10; F 1,18 = 26.40, **p < 0.0001, ANOVA). ( D ) Although the temporal pattern of locomotion differs between genotypes there is no significant difference in daily activity averaged over multiple days (mean ± SEM; N = 10, F 1,18 = 0.1793, ANOVA). ( E – G ) Addition of Meth to the drinking water of C57BL/6 mice lengthens the night-time activity bouts in a concentration-dependent manner. Averaged daily locomotor activity of individual mice at different Meth concentrations ( G ) derived from the time-span indicated by colored bars next to the representative actogram ( F ) and subjected to Butterworth filtering. The three night-time activity peaks before treatment (white triangles), transform to 2 peaks after exposure to the highest concentration (black triangles). The night-time bout lengthening is also reflected in the reduction of ultradian amplitude spectral density in the 1 to 5-hr range ( E , mean ± SEM, N = 7; F 2,20 = 8.08, p < 0.005, repeated measures ANOVA; *p < 0.05, **p < 0.01, post-hoc Bonferroni). White asterisks (in E ) indicate cage changes. DOI: http://dx.doi.org/10.7554/eLife.05105.007
Article Snippet: Low pass filtering (1-hr cut-off) of raw data was conducted using a
Techniques: Activity Assay, Concentration Assay, Derivative Assay